0105 - Cell Deformation within Isolated Chondrons Compressed in Agarose Constructs
نویسنده
چکیده
Introduction: Chondrocytes within articular cartilage are surrounded by a complex pericellular microenvironment which, together with the cell, is termed the chondron. The mechanical and physicochemical properties of the chondron matrix will undoubtedly influence the metabolism of the chondrocytes and their response to joint loading. The aim of the present study was to examine cell morphology in chondrons isolated using two different methods and visualised in both unstrained and compressed agarose constructs. This methodology was combined with immunolocalisation of matrix components to provide insight into the mechanical integrity of the chondrons.
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